体育平台大全与服务信息介绍

中药与天然药物的生物转化、提取加工及功效评价。

1．Ruijiao Yao, Jing Wang, Wenyan Xiao, Zhengwen Li, Yong Jiang, Jia Li, Zhengyou He, Sichong Ren, Microbial fermentation enhances activities of Panax japonicus against renal fibrosis and vascular calcification with chronic kidney disease via Chikusetsusaponin IVa enrichment and TGF-β1/Smad3 pathway, International Journal of Food Science and Technology, Volume 60, Issue 2, July 2025, vvaf269, //doi.org/10.1093/ijfood/vvaf269
2．Li Z, Li Y, Jiang T, Wang Y, Li C, He Z. Quercetin and Its Metabolites: Mechanistic Insights as the Basis of Their Therapeutic Potential in NAFLD and HCC. Molecules. 2025 Nov 17;30(22):4441. doi: 10.3390/molecules30224441.
3．Ruijiao Yao, Zhengyou He, Wenyi Jiang, Xia Zeng, Miao Zheng, Jing Wang, Zhengwen Li, Yong Jiang, Jia Li. Comparative study on the efficacy of Panax japonicus and its stem-leaf saponins in alleviating renal fibrosis and vascular calcification in mice with chronic kidney disease. Food Bioscience, Volume 71, 2025, //doi.org/10.1016/j.fbio.2025.107100.
4．Jing Wang, Ruijiao Yao, Xia Zeng, Zhiyang Chen, Miao Zheng, Zhengyou He.Research Advances and Application Prospects of Lactic Acid Bacteria Fermentation of Chinese Herbal Medicines.HSOA J Altern Complement Integr Med 2025, 11: 585 DOI: 10.24966/ACIM-7562/100585
5．He Z, Jiang W, Yao R, Xiao W, Chen Z, Zheng M, Zeng X, Li J, Li Z, Jiang Y. Comparison of Anti-Renal Fibrosis Activity of Eucommiae cortex Extract and Its Microbial Fermentation Products. Pharmaceuticals (Basel). 2025 May 19;18(5):747. doi: 10.3390/ph18050747. PMID: 40430564; PMCID: PMC12114716.
6．Chen Z, He Z, Qin J. Natural Deep Eutectic Solvents for the Extraction of Mulberroside A from White Mulberry Root Bark. ACS Omega. 2025 Apr 21;10(17):17221-17227. doi: 10.1021/acsomega.4c08800. PMID: 40352504; PMCID: PMC12059941.
7．Jiang W, He Z, Yao R, Xiao W, Chen Z, Zeng X, Zheng M, Wang J, Li J, Jiang Y. Eucommiae cortex extract alleviates renal fibrosis in CKD mice induced by adenine through the TGF-β1/Smad signaling pathway. J Nat Med. 2025 Jan;79(1):170-179. doi: 10.1007/s11418-024-01848-5. Epub 2024 Oct 24. PMID: 39443397.
8．Jiang W, He Z, Yao R, Chen Z, Zeng X, Zheng M, Wang J, Li J, Jiang Y. Preparation of Pinoresinol and Dehydrodiconiferyl Alcohol from Eucommiae Cortex Extract by Fermentation with Traditional Mucor. Molecules. 2024 Jun 23;29(13):2979. doi: 10.3390/molecules29132979. Erratum in: Molecules. 2025 Feb 27;30(5):1081. doi: 10.3390/molecules30051081. PMID: 38998931; PMCID: PMC11243097.
9．Lu L, Wang J, Wang C, Zhu J, Wang H, Liao L, Zhao Y, Wang X, Yang C, He Z, Li M. Plant-derived virulence arresting drugs as novel antimicrobial agents: Discovery, perspective, and challenges in clinical use. Phytother Res. 2024 Feb;38(2):727-754. doi: 10.1002/ptr.8072. Epub 2023 Nov 28. PMID: 38014754.
10．Luo QY, Cao HF, Liu SK, Wu M, Li SS, Zhang ZQ, Chen AJ, Shen GH, Wu HJ, Li ML, Liu XY, Jiang Y, Bi JF, He ZY. Novel liquid fermentation medium of Cordyceps militaris and optimization of hydrothermal reflux extraction of cordycepin. J Asian Nat Prod Res. 2020 Feb;22(2):167-178. doi: 10.1080/10286020.2018.1539080. Epub 2018 Dec 3. PMID: 30507305.

参与国家级重大科技攻关项目3项、上海市科技公关项目4项；负责四川省科技厅重点产品开发项目2项、四川省中医药管理局重大支撑项目1项、德阳市及凉山州科技局科技攻关项目3项、企业联合攻关项目30余项。科研成果获四川省科技进步奖三等奖2项，成都市科技进步奖二等奖2项；团队获国药集团青年文明号；指导本科生获国际大学生创新大赛获省级银奖1项、全国大学生生命科学竞赛省级三等奖1项。负责的主要科研项目有：
1．银杏黄酮提取工艺与银杏茶研发（四川省科技厅重点产品项目）
2．高原特色艾草精深加工技术研究应用（四川省科技厅重点产品项目）
3．银杏密植采叶园标准化种植化建设（四川省中医药管理局重大支撑项目）
4．云芝胞内糖肽的生产工艺开发
5．枣仁安神液注册标准变更研究
6．复方RSDT中药6.1类新药的技术开发
7．新型医用消毒剂的技术开发
8．银杏达莫注射液非临床安全性再评价研究
9．雪莲注射液安全性再评价的临床前研究
10．香菇多糖原料药的研究
11．荣保灵芝1号的技术开发
12．灵芝三萜的制备工艺与质量研究
13．新型植物消毒健康产品的技术研发
14．抗耐药菌医疗新产品的技术研发
15．新型抗菌（含超级细菌MRSA）日化产品的技术研发
16．大方县野生天麻资源的菌种选育及功能性大健康产品开发
授权专利：
1．一种含人参次苷及其苷元的组合物、制备方法和应用。2024年，中国专利ZL 2022 1 0741330.0
2．一种嵌合型银基纳米溶菌酶、制备方法及其应用。2024年，中国专利ZL 2022 1 0907650.9
3．一种复合碘消毒液及其制备方法。2023年，中国专利ZL 2021 1 1086028.8
4．一种纳米银颗粒、制备方法及其应用。2023年，中国专利ZL 2022 1 0860156.1
5．高抗人源肿瘤细胞活性的灵芝总三萜纯化物及其纯化方法。2018年，中国专利ZL 201410551800.2
6．含莼菜的复方皮肤外用制剂及制备方法和应用。2015年，中国专利ZL 201510364929.7
7．一种灵芝总三萜组合物及其制备方法。2015年，中国专利ZL201510421407.6
8．香菇多糖及其提取纯化方法。2017，中国专利ZL201510365038.3
9．一种高银杏萜类内酯含量的银杏达莫注射液的制备方法。2013年，中国专利ZL201210178017.7